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Millipore
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List Biological Laboratories
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Merck KGaA
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AnaSpec
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Millipore
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List Biological Laboratories
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Promega
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Peptide Institute
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Millipore
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Thermo Fisher
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Millipore
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Image Search Results
Journal: Microcirculation (New York, N.Y. : 1994)
Article Title: Differential hyperpolarization to substance P and calcitonin gene-related peptide in smooth muscle versus endothelium of mouse mesenteric artery
doi: 10.1111/micc.12733
Figure Lengend Snippet: Hyperpolarization to SP occurs through KCa channels. (A) Representative recording of Vm in an intact MA (+EC) demonstrates attenuation of SMC hyperpolarization to SP in the presence of KCa channel inhibitors charybdotoxin (ChTx; 10−7 M) + apamin (AP; 3 × 10−7 M). B) Summary data for Vm responses to SP in SMCs from intact MAs (+EC) studied at 37°C under control (from Figure 1) conditions and during KCa channel inhibition. (C) Summary data for Vm responses to SP for ECs within endothelial tubes studied at 32°C during the absence or presence of KCa channel inhibitors. Values are means ± SEM for n = 5 per group. B = baseline Vm. W = washout in control PSS. #p < 0.05 vs. baseline (prior to application of SP) Vm in vessels treated with ChTx + AP. †p < 0.05 vs. control
Article Snippet: Apamin (Cat. #60772), CGRP (Cat. #20682),
Techniques: Control, Inhibition
Journal: Microcirculation (New York, N.Y. : 1994)
Article Title: Differential hyperpolarization to substance P and calcitonin gene-related peptide in smooth muscle versus endothelium of mouse mesenteric artery
doi: 10.1111/micc.12733
Figure Lengend Snippet: KCa channels contribute to hyperpolarization of ECs more than SMCs in response to CGRP. (A) Representative recording of Vm from an EC within a MA endothelial tube demonstrates lack of hyperpolarization to CGRP in the presence of charybdotoxin (ChTx; 10−7 M) + apamin (AP; 3 × 10−7 M); note hyperpolarization to ACh (5 min) following washout, confirming EC viability. (B) Summary data for Vm responses to CGRP in SMCs from intact MAs (+EC) studied at 37°C under control conditions (from Figure 2) or during KCa channel inhibition. (C) Summary data for Vm responses to CGRP in ECs within endothelial tubes studied at 32°C in the presence or absence of KCa channel inhibitors. Values are means ± SEM for n = 5 per group. B = baseline Vm. W = washout in control PSS. #p < 0.05 vs. baseline (prior to application of CGRP) Vm in vessels treated with ChTx + AP. †p < 0.05 vs. control. *p < 0.05 EC vs. SMC Vm
Article Snippet: Apamin (Cat. #60772), CGRP (Cat. #20682),
Techniques: Control, Inhibition